Sulfamethoxazole trimethoprim: 7 things you should know

what is the drug bactrim

No interference occurs, however, if methotrexate is measured by a radioimmunoassay (RIA). Avoid coadministration of BACTRIM and leucovorin during treatment of P. jirovecii pneumonia (see WARNINGS). BACTRIM is contraindicated in pediatric patients less gary jackson author at sober-home than 2 months of age. For the treatment of enteritis caused by susceptible strains of Shigella flexneri and Shigella sonnei when antibacterial therapy is indicated. The recommended dosage of Bactrim depends on the type of infection being treated.

Medications & Supplements

what is the drug bactrim

Possibly, but Bactrim is not approved to treat cellulitis or sexually transmitted infections (STIs). If you’re having side effects with Bactrim, talk with your doctor or pharmacist. Ask your doctor or pharmacist if you have questions about how Bactrim compares with other medications. In general, symptoms of an allergic reaction can be mild or serious. You can learn more about possible symptoms in this article.

How Long Should a UTI Last After Antibiotics?

The trimethoprim component of BACTRIM has been noted to impair phenylalanine metabolism, but this is of no significance in phenylketonuric patients on appropriate dietary restriction. BACTRIM-induced thrombocytopenia may be an immune-mediated disorder. Severe cases of thrombocytopenia that are fatal or life threatening have been reported. Thrombocytopenia usually resolves within a week upon discontinuation of BACTRIM. This document does not contain all possible side effects and others may occur.

  1. The sulfonamides should not be used for treatment of group A β-hemolytic streptococcal infections.
  2. There have been reports of marked but reversible nephrotoxicity with coadministration of BACTRIM and cyclosporine in renal transplant recipients.
  3. Your doctor may order this test to check your kidney function.
  4. The dose of this medicine will be different for different patients.
  5. The dosage is based on your medical condition and response to treatment.

Typical dosages in adults

If you have symptoms of a severe allergic reaction, such as swelling or difficulty breathing, call 911 or your local emergency number right away. These symptoms could be life threatening and require immediate medical care. If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away.

Generic Name(S): sulfamethoxazole-trimethoprim

what is the drug bactrim

Both sulfamethoxazole and trimethoprim distribute to sputum, vaginal fluid and middle ear fluid; trimethoprim also distributes to bronchial secretion, and both pass the placental barrier and are excreted in human milk. Use of BACTRIM at high doses and/or for extended periods of time may cause bone marrow depression manifested as thrombocytopenia, leukopenia and/or megaloblastic anemia. If signs of bone marrow depression occur, the patient should be given leucovorin 5 to 15 mg daily until normal hematopoiesis is restored. BACTRIM, specifically the trimethoprim component, can interfere with a serum methotrexate assay as determined by the competitive binding protein technique (CBPA) when a bacterial dihydrofolate reductase is used as the binding protein.

MRSA Quiz: Infection Symptoms & Treatment

If you have serious side effects from Bactrim, call your doctor right away. But if you think you’re having a medical emergency, you should call 911 or your local emergency number. Here’s a list of some of the mild side effects that Bactrim can cause.

Caution should be exercised when BACTRIM is administered to a nursing woman, especially when breastfeeding jaundiced, ill, stressed, or premature infants because of the potential risk of bilirubin displacement and kernicterus. Cases of hypoglycemia in non-diabetic patients treated with BACTRIM are seen rarely, usually occurring after a few days of therapy. Patients with renal dysfunction, liver disease, malnutrition or those receiving high doses of BACTRIM are particularly at risk.

Get medical help right away if you get sunburned or have skin blisters/redness. This medication may cause live bacterial vaccines (such as typhoid vaccine) to not work well. Tell your health care professional that you are using this medication before having any immunizations/vaccinations. Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.

If your doctor prescribes Bactrim for your mild to moderate UTI, your dose will likely be one 800 mg/160 mg tablet or two 400 mg/80 mg tablets. Typically, you’ll take this every 12 hours for 10–14 days. This is the typical recommended dosage the difference between alcohol and ethanol of Bactrim for people with UTIs. To prevent pneumocystis pneumonia in adults, the typical dosage is one tablet of Bactrim DS (800 mg/160 mg) taken once daily. Doctors prescribe Bactrim or Bactrim DS to treat various bacterial infections.

Doctors may prescribe Bactrim or Bactrim DS off-label for these uses. With off-label use, doctors prescribe a drug for a purpose other than what the FDA has specifically approved it for. Traveler’s diarrhea is defined as having at least three episodes of diarrhea (loose, watery stools) in a 24-hour period during travel abroad. It’s often caused by consuming contaminated food or water. Or it may be caused by consuming water that contains different bacteria than what your body is used to at home. Symptoms commonly include trouble breathing, chest pain, and fever.

what is the drug bactrim

However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. As with any drug, never change your alcohol withdrawal dosage of Bactrim without your doctor’s recommendation. If you have questions about the dosage of Bactrim that’s best for you, talk with your doctor.

The effects of the sulfonamide class of antibiotics on the fetus have not been adequately studied. Therefore, physicians may use them if the benefits are deemed to outweigh potential risks. On the other hand, use of sulfonamides near term (that is, near the ninth month of pregnancy) may cause bilirubin to be displaced from proteins in the infant’s blood. Displacement of bilirubin can lead to a dangerous condition called kernicterus in which the bilirubin damages the brain. For this reason, sulfonamides should not be used near term birth.

Skipping doses can increase your risk of infection that is resistant to medication. This medicine will not treat a viral infection such as the flu or a common cold. In adults, 800 mg of sulfamethoxazole and 160 mg of trimethoprim every 12 hours for five days. The incidence of congenital abnormalities was 4.5% (3 of 66) in those who received placebo and 3.3% (4 of 120) in those receiving sulfamethoxazole and trimethoprim. There were no abnormalities in the 10 children whose mothers received the drug during the first trimester.

In this case, the recommended dosage of Bactrim is one 800 mg/160 mg tablet or two 400 mg/80 mg tablets. Bactrim (sulfamethoxazole/trimethoprim) is a brand-name drug that’s prescribed for certain infections. The dosage can vary depending on the condition being treated. Sulfamethoxazole and trimethoprim is a combination antibiotic used to treat ear infections, urinary tract infections, bronchitis, traveler’s diarrhea, shigellosis, and Pneumocystis jiroveci pneumonia. Possibly, but older adults (people ages 65 years and older) should use Bactrim and Bactrim DS with caution.

If you have these lab tests done, be sure to tell the healthcare professional carrying out the test that you’re taking Bactrim. There are currently no reports of Bactrim interacting with food. There are no specific foods you need to avoid while taking Bactrim. If you have questions about eating certain foods during your treatment with Bactrim, talk with your doctor.

If you cannot avoid being in the sun, wear protective clothing and sunscreen. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Talk with your doctor if you have questions about what to expect with Bactrim treatment. For more information about your specific dosage, talk with your doctor. Mixed medicine must be used within 2 to 6 hours depending on the amount of diluent in the mixture. Call your pharmacist if the medicine looks cloudy, has changed colors, or has particles in it.

The steady-state mean plasma levels of free and total sulfamethoxazole were 57.4 μg/mL and 68.0 μg/mL, respectively. These steady-state levels were achieved after three days of drug administration.1 Excretion of sulfamethoxazole and trimethoprim is primarily by the kidneys through both glomerular filtration and tubular secretion. For treating middle ear infection in children ages 2 months and older, the dose of Bactrim depends on your child’s body weight in kg. Your child’s doctor will calculate the dose based on the two active ingredients in Bactrim. The recommended dose is 40 mg/kg of sulfamethoxazole and 8 mg/kg of trimethoprim per day.

Alcohol is not known to interact with Bactrim or Bactrim DS. If you have questions about how much alcohol is safe to drink while taking this medication, talk with your doctor or pharmacist. Using more than the recommended dosage of Bactrim or Bactrim DS can lead to serious side effects. Do not use more Bactrim or Bactrim DS than your doctor recommends. If doctors prescribe Bactrim for an older adult, they may prescribe a lower dosage.

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